Assist. Prof. Dr. Dilek Şendil Keskin

 

 

Department of Engineering Sciences,

Middle East Technical University (METU),

06531 ANKARA TURKEY

Phone: 90 312 2102389

Fax: 90 312 2101269

E mail: dkeskin@metu.edu.tr

 

 

AREAS OF INTEREST 

 

Biomaterials
- Biodegradable Polymers
- Controlled Drug Delivery
- Hard Tissue Repair

 

GRANTS AND SCHOLARSHIPS 

 

1999-2000            Sientific and Technical Research Council of Turkey (TUBITAK) Grant for PhD Studies (1 year) Northeastern University and Tufts University, Boston USA.

 

PROJECTS

 

Research Associate; Controlled Release of Analgesics for the Alleviation of Chronic Pain,  (TUBITAK –Integrated Ph.D. Programme) (1997-2001)

Research Associate; Construction of a Dual System of a Biodegradable Mesh and Collagen Based Bone Morphogenetic Protein Delivery System for the Treatment of Bone Fractures,  (Grant No: TUBITAK) (2001-2003)

Research Associate; Construction of Bone Morphogenetic Protein and Antibiotic Loaded Biodegradable Polymeric Controlled Release Systems for the Treatment of Bone Fractures, State Planning Organization Project (2002-2005)

Research Associate; Substans P İçeren PHBV İmplantları ile Periostal Kemik İyileşmesinin Hızlandırılması, (ODTÜ, BAP- 2002-2004)

Research Associate; Vankomicin İçeren Kontrollü Salım Çubuklarının Geliştirilmesi ve İn Situ İncelenmesi, (ODTÜ, BAP- 2002-2005)

Project Manager; Biomechanical Evaluation of Effects of Estrogen, Selective Estrogen Receptor Modulator Drugs and Vitamin K2 on Osteoporotic Bone (ODTÜ, BAP- 2003-2004)

 

Research Associate; Recovery of Sericin Protein from Textile Wastewaters and Investigation of its Reuse Areas , (TUBITAK 2006-)

Research Associate; Evaluation of Different Bioactive Agents for Treatment of Osteoarthritis Under Dynamic and Static Mechanical Stimulation with Cell Culture Techniques , (TUBITAK 2005-)

Coordinator; Development of Bioglass/Calcium Sulphate Based Composite Materials with Different Compositions and Investigation of Their Mechanical and Bioeffectiveness Properties , (TUBITAK 2005-)

Research Associate; Production of Nanoalumina-Hydroxyapatite Bioceramic Composites and Evaluation of Their Biocompatibilities, (METU-BAP 2005-)

PUBLICATIONS

 

D. Sendil-Keskin and V.Hasırcı, Controlled Release of Bioactive Agents in Gene Therapy and Tissue Engineering. in Tissue Engineering, Stem Cells and Gene Therapies. Advances in Experimental Medicine and Biology Vol 534 , Kluwer Academic /Plenum Publishers, New York, 2003,  ed Y.Murat Elcin, pp.279-296,

 

D. Şendil, I.Maszcynska, D. B. Carr, A.W. Lipkowski, D.L. Wise, V. Hasırcı, Control of Severe-Chronic Pain via Intrathecal Polymeric Implants. Biomaterials, 24, 1969-76, 2003.

 

D. Şendil, H. Altunay, D.L. Wise, V. Hasırci, In Vivo Pain Relief Effectiveness of Analgesic-Anesthetic Carrying Biodegradable Controlled Release Rod Systems. Journal of Biomaterials Sciences, Polymer Edn, 14, 6, 497-514, 2003.

 

Bonney, I., Şendil-Keskin, D., Hasirci, V., Lipokwski, A.W., Carr, D. B. "Technologies for Analgesic Drug Delivery in the Treatment of Chronic Pain",   MD Consult Clinical Insights

Online: http://ho-me.mdconsult.com/das/stat/view/29916685/pers?nid=111003& sid=0&pos= innovators)

 

D. Şendil, D.L. Wise, V. Hasırcı, Assessment of Biodegradable Controlled Release Rod Systems for Pain Relief in Journal of Biomaterials Sciences, Polymer Ed. 2002; 13, 1-15.

 

D. Şendil, I.Maszcynska, D. B. Carr, A.W. Lipkowski, D.L. Wise, V. Hasırcı, Control of Severe-Chronic  Pain via Intrathecal Polymeric Implants. (Extended abstract). J. of Technology and Health Care. 10(3-4), 334, 2002.

 

D. Şendil, I.Maszcynska, D. B. Carr, A.W. Lipkowski, D.L. Wise, V. Hasırcı, Control of Severe-Chronic  Pain via Intrathecal Polymeric Implants. (Extended abstract). J. of Technology and Health Care. 10(3-4), 334, 2002.

 

D. Şendil,  D.L. Wise, V. Hasırcı, Pain Reliever Delivery From Two Different Controlled Release Systems.  (Extended abstract). J. of Technology and Health Care. 10(3-4), 338, 2000.

 

D. B. Carr, D. Şendil, Current approaches to analgesic drug delivery for chronic pain. J. of Technology and Health Care. 10(3-4), 227, 2002.

 

A. Tezcaner, A. Ozkul, D. Sendil, K. Bugra, H. Altunay, V. Hasırcı, METU Retinal Pigment Epithelium Cell Culture on Thin Biodegradable Poly (hydroxybutyrate-co-hydroxyvalerate) / Sucrose Acetate Isobutyrate Films. (Extended abstract). J. of Technology and Health Care. 10(3-4), 297, 2002.

 

V. Hasırcı, D. Şendil, L. Goudas, D. Carr, D.L. Wise, Controlled Release Pain Management Systems Handbook of Pharmaceutical Controlled  Release Technology, Marcel Dekker, 787-806,  2000.

 

D Şendil, İ. Gürsel, V. Hasırcı, Preparation of  PHBV Foams and Investigation of Their Potential for Drug Release, Turkish Journal of Medical Sciences, 30(1), 9-14, 2000.

 

D. Sendil, İ. Gürsel, D.L. Wise, V. Hasırcı,  Antibiotic Release From Biodegradable PHBV Microparticles. Journal of Controlled Release, 59, 207-217, 1999.

 

D. Şendil, İ. Gürsel, D.L.Wise, V. Hasırcı, Antibiotic Release From PHBV Microparticles. Biomedical Science and Technology, Recent Developments in the Pharmaceutical and Medical Sciences, 89-96, Plenum Press, New York, 1998.

 

PRESENTATIONS

 

D. Sendil Keskin, A. Tezcaner, P. Korkusuz, F. Korkusuz, V. Hasirci. Influence of rh BMP Loaded Collagen/PLLA/SAIB CRS on Bone Healing. 10th Biomedical Science and Technology Symposium at METU Campus of Northern Cyprus. 10-12 October 2003.

D. Şendil Keskin, I.Bonney, V. Hasırcı, A.W. Lipkowski, D. B. Carr Polymers for Analgesic Drug Delivery in the treatment of Chronic Pain. 10th Biomedical Science And Technology Symposium at METU Campus of Northern Cyprus10-12 October 2003.
A. Tezcaner, D Sendil Keskin, H. Altunay, F. Korkusuz, V. Hasırcı... Effect of Controlled Substance P Release Systems on Bone Healing. 10th Biomedical Science and Technology Symposium at METU Campus of Northern Cyprus10-12 October 2003.

Z. Gaimalov, D Sendil Keskin, V. Hasırcı. 10th Biomedical Science And Technology Controlled Release of Rofecoxib From Poly(D, L-Lactide- Co-Glycolide) and Poly(L-Lactic Acid) Microspheres for Brain Cancer Therapy. 10th Biomedical Science and Technology Symposium at METU Campus of10-12 October Northern Cyprus 2003.

D. Sendil Keskin, A. Tezcaner, P. Korkusuz, F. Korkusuz, V. Hasirci Evaluation of rhBMP Loaded Collagen/PLLA/SAIB Delivery and Mesh System for Repair of Bone Defect. 18th European Conference on Biomaterials Stuttgart, Germany 01-04
October 2003.

Dilek Şendil Keskin, Ayşen Tezcaner, Vasıf Hasırcı. BMP Releasing/ Structure Stabilizing Polymeric Systems: Construction and Characterization. The Nineth National Symposium on Biomedical Sciences and Technology (BIOMED 9), 19-22 September, 2002, Kemer, Antalya, Turkey.

Dilek Şendil Keskin, D.L.Wise, Vasıf Hasırcı. Pain Reliever Delivery From An Interpenetrating Controlled Release System. 17th European Conference on Biomaterials. 11-14 September, 2002, Barcelona, Spain.

D. Şendil, I.Maszcynska-Bonney, D. B. Carr, A.W. Lipkowski, D.L. Wise, V. Hasırcı Pain Control via Intrathecal Polymeric Implants. The Eight National Symposium on Biomedical Sciences and Technology (BIOMED 8), 5-8 September, 2001, METU, Ankara,Turkey. 

D. Şendil,  D.L. Wise, V. Hasırcı, Pain Reliever Delivery From Two Different Controlled Release Systems. The Eight National Symposium on Biomedical Sciences and Technology (BIOMED 8), 5-8 September, 2001, METU, Ankara,Turkey. 

A. Tezcaner, A. Ozkul, D. Sendil, K. Bugra, H. Altunay, V. Hasırcı, METU Retinal Pigment Epithelium Cell Culture on Thin Biodegradable Poly (hydroxybutyrate-co-hydroxyvalerate) / Sucrose Acetate Isobutyrate Films. The Eight National Symposium on Biomedical Sciences and Technology (BIOMED 8), 5-8 September, 2001, METU, Ankara,Turkey.

D. Şendil, V. Hasırcı, D.L.Wise Controlled Drug Releasing Systems for the Alleviation of Chronic Pain Northeastern University, Chemical Engineering, 18th  May, 2000, Boston, USA.

D Şendil, İ. Gürsel, V. Hasırcı, Preparation of  PHBV Foams and Investigation of Their Potential for Drug Release. The Fifth National Symposium on Biomedical Sciences and Technology (BIOMED 5), 16-18 December, 1998, METU, Ankara,Turkey. 

D Şendil, İ. Gürsel, D.L.Wise, V. Hasırcı, Tetracycline Release From Biodegradable Polyesters For Treatment of Periodontal Diseases. Fourth European Congress of  Pharmaceutical Sciences, 11-13 September, 1998, University of  Milan, Italy. 

D Şendil, İ. Gürsel, D.L.Wise, V. Hasırcı, Controlled Release of Antibiotics From Biodegradable Microspheres, The First International Postgraduate Research Symposium on Pharmaceutics (IPORSHIP), 24-25 July, 1998, Istanbul University, Turkey.

D Şendil, İ. Gürsel, D.L.Wise, V. Hasırcı, Antibiotic Release From PHBV Microparticles. The Fourth International Symposium on Biomedical Science and Technology  (BIOMED 4), 15-17 September, 1997, Istanbul, Turkey.

D Şendil, İ. Gürsel, D.L.Wise, V. Hasırcı, Tetracycline Release From PHBV Microcapsules.  Proceedings of the Third National Symposium On Biomedical Science and Technology (BIOMED 3), 11-14 December 1996, University of Uludag,  Bursa, Turkey.

 

 

Lecture 1